Mood Disorders

PsychCare Consultants Research LLC offers a study of Bipolar disorder in children and adolescents. For more information, call Toni Ransdell at 314-608-8781.

Midwest Research Group/St. Charles Psychiatric Associates is conducting a clinical trial of medication for adults aged 18 to 65 who are diagnosed with Bipolar I. This study utilizes cariprazine to evaluate its effectiveness for adults experiencing mania or depression. Participants will receive this medication in prevention of relapse.

Participants will receive study medication or placebo, physician consultation, travel expenses and compensation for their time.  No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

Washington University is enrolling individuals with bipolar disorder or depression for a research study to examine thinking and decision-making. Participants must be between the ages of 18 and 60. The study involves five visits. Up to $500 in monetary compensation is available for qualified participants. Call 314-662-0906 for more information.

Midwest Research Group/St. Charles Psychiatric Associates is conducting four (4) clinical trials of medications for adults, age 18 and older, who are diagnosed with depression.

• Study #1 is for adults who continue to have depressive symptoms even after trying at least one antidepressant medication. All participants are guaranteed to receive an open-label, approved antidepressant medication. An add-on medication will be provided with the goal of decreasing depressive symptoms and increasing energy levels.
• Study #2 is for adults with treatment-resistant depression, meaning they have tried several different medications and “nothing seems to work.” This study only lasts three weeks and includes coming into the office three times a week.
• Study #3 focuses on people with treatment resistant depression who either are taking an antidepressant medication or not. It is a novel medication thought to combat depression in a different way than conventional medications.
• Study #4 is for adults that are stable on an antidepressant and things are going well. It requires participants to complete surveys about their depression and complete tasks that measure cognition. This study requires 3-5 study visits and pays $75 each time.

Participants in this study will receive study medication or placebo, physician consultation, travel expenses and compensation for their time. No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

Psychiatric Care and Research Center conducts ongoing trials for various diagnoses, including depression in adults. Visit www.pcrc-stl.com or call 636-244-3593 for more information.

Midwest Research Group/St. Charles Psychiatric Associates is conducting a clinical trial of medication for children ages 7 to 17 who are diagnosed with depression. This study compares two approved antidepressant medications (one approved for adults and one approved for children) to see which one works better. Children in this study also receive counseling services at no cost. Participants interested in this study must have suffered from depressive symptoms for the last six weeks and are looking for an alternative medication.

Participants in this study may receive study medication or placebo, physician consultation, travel expenses and compensation for their time.  No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

Midwest Research Group/St. Charles Psychiatric Associates is conducting a clinical trial of medication for women between the ages of 18 and 45 who are diagnosed with Post-partum Depression. This study site is one of ten in the country using Brexanolone, a neural steroid which helps to replace the drop in allopregnanolone levels which are known to occur post-partum. This medication has been granted Breakthrough Therapy designation by the FDA. 

Participants must be less than 6 months post-partum, and experienced depression onset that began no earlier than the third trimester and no later than the first four weeks following delivery.

Participants in this study may receive study medication or placebo, physician consultation, travel expenses and compensation for their time.  No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

PsychCare Consultants Research LLC offers a study of Treatment-Resistant Depression in persons who have been diagnosed with major Depression or Bipolar disorder and who are at least 18 years old. For more information, call Toni Ransdell at 314-608-8781.

Washington University seeks participants for a research study to look at the safety and efficacy of Intracalvarial Prefrontal Cortical Stimulation (IPCS) for persons who experience severe treatment-resistant depression (symptoms that have not improved after trying two or more medications).

IPCS is a minimally invasive treatment involving surgical placement of an electrode device in the participant's skull. Over time, electric pulses will be sent from the device to affect specific areas of the brain thought to be involved with depression.

The study includes:

• CT and MRI scans to identify where to implant the device
• completion of baseline assessments for data collection
• surgical implantation of the device in the skull
• surgical implantation of another device (a pulse generator) below the skin in the right side of the chest
• implantation of an under-the-skin wire to connect the devices
• a series of study visits over a period of up to 18 months
• access to Washington University Neurosurgery and Psychiatry on-call physician services for urgent study-related issues throughout participation

Eligibility includes:

• diagnosis of chronic (greater than or equal to two years) or recurrent (multiple prior episodes) depression and are currently experiencing a major depressive episode as defined by DSM V criteria
• diagnosed with treatment resistant depression
• between the ages of 21 and 80

To discuss more details and participation, contact Karen Flavin, RN, CRC, at 314-747-6998 or This email address is being protected from spambots. You need JavaScript enabled to view it..

Washington University's Department of Psychiatry is seeking participants who experience treatment-resistant depression. The study aims to determine whether the sedative Propofol has antidepressant effects through altering sleep in adults with treatment-resistant depression. There are up to four study visits ranging from one to four hours each. There will be vital sign collection, questionnaires throughout the study, and infusions of Propofol through an IV. Benefits and risks will be discussed with volunteers as part of the informed consent process. Up to $305 is provided in compensation. Criteria is:

• Participants must be over 60 years of age.
• Participants must currently have depression and no success after at least two types of oral antidepressant medications of adequate duration.
• Potential participants will be assessed for sleep deficiencies.
• Participants must have no ongoing heart disease, congestive heart failure, cardiomyopathy, recent stroke in the past year, morbid obesity (BMI > 35), ECT/TMS/vagal nerve stimulation in the last six weeks, resting pulse < 60, or prior reaction to Propofol.

For more information, contact Aris Perez at 314-747-8906 or at This email address is being protected from spambots. You need JavaScript enabled to view it..